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Archiver > GENEALOGY-DNA > 2006-11 > 1163478503


From: (John Chandler)
Subject: Re: [DNA] Conference [recLOH]
Date: Mon, 13 Nov 2006 23:28:23 -0500 (EST)
References: <539.c7d7c43.32821267@aol.com> <455744E3.8030506@earthlink.net><REME20061113210621@alum.mit.edu> <45593B29.5080108@sbcglobal.net>
In-Reply-To: <45593B29.5080108@sbcglobal.net> (aburto@sbcglobal.net)


Al wrote:
> Could you show an example John? I don't understand the "alternative
> conformation", how does it work ...

In the "normal" configuration, there are two separate palindromes,
labeled P1 and P2, each having one pair of DYS464 markers and one
pair of DYS725 markers. P1 also has DYS459 and CDY (DYS724) -- again
one pair of each. The point is that the DNA sequence of the fold-over
loop is the same for both P1 and P2, and so there is another way to
match things up -- by laying out the entire unfolded P2 palindrome
alongside the middle of the unfolded P1 palindrome. You can see it
graphically on Thomas' palindrome map at dna-fingerprint.com.

John Chandler

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