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Archiver > GENEALOGY-DNA > 2006-09 > 1157121303


From: "Alfred A. Aburto Jr." <>
Subject: Re: [GENEALOGY-DNA] can we do better for genetic distance?
Date: Fri, 01 Sep 2006 07:35:03 -0700
References: <3f5.941377e.32298c44@aol.com>
In-Reply-To: <3f5.941377e.32298c44@aol.com>


> wrote:

>In a message dated 9/1/2006 5:59:03 AM Pacific Daylight Time,
> writes:
>
>
>
>>Assuming 1 step differences is a start of course and the idea below
>>would still give one a better estimate than genetic distance alone.
>>
>>I wonder how often multiple step differences occur? Any ideas?
>>If they do occur often then what could one do to handle them in a simple
>>algorithm?
>>
>>
>
>Gusmao's meta-analysis of father/son studies (combining data from 6 papers)
>gives these numbers for 64273 "allele transfers" (not 64273 father/son pairs,
>as not every study looked at the same markers)
>
>85 one-step increases
>46 one-step decreases
>3 two-step increases
>1 two-step increase
>1 three-step increase
>1 four-step decrease
>
>Total 137, for an overall average of .00213
>
>Ann Turner
>

Thanks Ann!

percent occurrence:
one-step about: 96%
two-step about: 3%
three & higher-step about: 1%

So the one-step assumption seems good and so does Sam's suggestion and
taking Doug's idea about how to treat two-step mutations one
should/could obtain a nice little algorithm giving a better idea of the
closeness or distance between haplotypes ... I suppose instead of
"genetic distance" one could call it "temporal distance"? Just a thought :-)
Al

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